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To prescribe isotretinoin, the prescriber must access the ipledge system via the internet www.

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PRECAUTIONSALSO SEE WARNINGSTreatment should be limited to relatively small areas of the body at one time since some patients experience a transient skin reddening and a mild burning sensationwhich does not preclude treatment.

Long-term animal studies to determine the carcinogenic potential of tretinoin have not been performedStudies in hairless albino mice suggest that tretinoin may accelerate the tumorigenic potential of weakly carcinogenic light from a solar simulatorIn other studieswhen lightly pigmented hairless mice treated with tretinoin were exposed to carcinogenic doses of UVB lightthe incidence and rate of development of skin tumors was reducedDue to significantly different experimental conditionsno strict comparison of these disparate data is possibleAlthough the significance of these studies to man is not clearpatients should avoid or minimize exposure to sun.

Once the acne lesions have responded satisfactorilyit may be possible to maintain the improvement with less frequent applicationsor other dosage forms.

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after the next step, that can no longer happen, which suggests that this step is one of the most important rate-limiting feedback loops in the creation of tretinoin and of overall vitamin a homeostasis.

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